SymplPaste offers better-than-fluoride protection. The difference is nano-hydroxyapatite (or "n-HAp"). n-HAp was first developed by NASA in the 1970s to help astronauts returning from space with loss of bone density due to weightlessness. Teeth - like bones - are built from hydroxyapatite, so n-HAp is better at addressing cavities and remineralizing teeth than fluoride is. The n-HAp in SymplPaste hinders plaque formation, reduces gingivitis, and helps with tooth sensitivity. Subtle-mint-flavored SymplPaste is also the cleanest toothpaste ever; it is non-GMO, vegan, and SLS-free.